Importantly, higher NFS and PCSK9 concentrations were observed in individuals with events than in those without (all P <  0.05), while the proportions of male sex, hypertension, blood pressure, smoking and drinking status; BMI, and triglyceride, total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), platelet count, AST, ALT, albumin, FPG, HbA1c levels were not significantly different in patients with and without (all P >  0.05). The gene discussed is ALB; the disease is Hypertension.