ALOX15 and cancer: For example, ALOX5, ALOXE3, ALOX15, and ALOX15B are responsible for ferroptosis in human cell lines derived from various cancer types (BJeLR, HT-1080 or PANC1 cells), while ALOX15 and ALOX12 mediate the derivation of non-small-cell lung cancer (NSCLC) p53 induced ferroptosis in H1299 cells, in which ALOX12 induced ferroptosis through TP53-mediated down-regulation of SLC7A11 [20, 24, 52, 53].