As the in vitro tests of tyrosinase inhibition and melanoma cell lines, didn’t involve the complex physiological in vivo conditions, and the absorption, metabolism, distribution and excretion of the test sample, many of the samples showed significant inhibitory activity against tyrosinase and melanoma cell lines in vitro, nevertheless, exhibited weakly effective or even ineffective in vivo [22, 23]. The gene discussed is TYR; the disease is melanoma.