CircRNA microtubule actin crosslinking factor 1 (circ_MACF1, also called hsa_circ_0011780 according to the circRNA ID of circBase database), produced by the head-to-tail splicing of exons of MACF1 mRNA, has been identified as an anti-tumor factor in NSCLC by binding to miR-544a to induce F-Box and WD repeat domain containing 7 (FBXW7) [15]. The gene discussed is MACF1; the disease is non-small cell lung carcinoma.