Thus, among these five gene sets, FAAO was found as the only gene set that could stratify CRC patients similarly as HALLMARK_PEROXISOME (Additional file 2: Fig. S5b); TCGA CRC patients with a relatively low FAAO score and high TIM3 expression (FAAOLowTIM3High) had the worst OS, which was validated in GSE39582 (Fig. 6a and b). The gene discussed is HAVCR2; the disease is colorectal carcinoma.