Regarding increased expression, the combined patient group showed an enrichment in “Primary immunodeficiency”, “Staphylococcus aureus infection”, “Systematic lupus erythematosus” (overlap with PD-L1 expression, Fig. 3A, C, supplemental Figs. 5 and 8), and “Endocytosis” (Overlap with altered processing, Fig. 3B, C, supplemental Figs. 6 and 8). Here, CD274 is linked to lupus erythematosus.