Simultaneously, mitochondrial membrane damage-related pathway (activating transcription factor-2 pathway), apoptosis-related pathway (telomeres, telomerase, cellular aging, and immortality pathway) and negative feedback repair-related pathway (GRB2 associated binding protein 1 signalosome and transforming growth factor-beta receptor signaling activates SMADs) could uncover some heterogeneity of cellular injury for sepsis. The gene discussed is HNF1B; the disease is Sepsis.