In addition, we observed the suppression of ESCC cell proliferation, migration, and invasion when the m6A modification in TNFR1 was removed (Figures 5F, 5G, and S4F), indicating that the m6A modification of TNFR1 also influences ESCC development. This evidence concerns the gene TNFRSF1A and esophageal squamous cell carcinoma.