TNFRSF1A and esophageal squamous cell carcinoma: IHC analysis in another 58 paired normal esophageal and ESCC samples (SYSUCC cohort; Table S3) showed that patients with advanced-stage (III/IV) disease were characterized by higher TNFR1 protein levels than those with early-stage disease (I/II) (p = 0.0013, Mann-Whitney test; Figure 7C).