Then, we detected the m6A levels of the TNFR1 transcript in 215 pairs of ESCCs and adjacent normal esophageal samples (SYSUCC cohort; Table S2) by using methylated RNA immunoprecipitation sequencing (MeRIP)-coupled quantitative real-time-PCR (qRT-PCR) and found that its m6A modification was elevated in ESCC tumors (Figure 2B). This evidence concerns the gene TNFRSF1A and esophageal squamous cell carcinoma.