Previous studies have reported the oncogenic role of TNFR1 in mouse skin,18 colon, and gastric tumorigenesis,19 and our findings consistently demonstrated that TNFR1 promotes ESCC cell proliferation and invasiveness in vitro; m6A modification of TNFR1 may play an important role in TNF-induced inflammatory response and tumorigenesis. The gene discussed is TNF; the disease is esophageal squamous cell carcinoma.