ATXN2 and cancer: However, integrated analysis of published ATXN2 PAR-CLIP-seq (HEK293T cells) data and m6A-seq data of our ESCC tissues revealed a high binding intensity for ATXN2 centered at m6A residues and vice versa for m6A in the global transcriptome level (Figure 3F), but whether and how ATXN2 regulates other m6A-modified transcripts in ESCC or other types of cancer should be investigated in the future.