TNFRSF1A and esophageal squamous cell carcinoma: However, the m6A levels of the TNFR1 transcript were positively correlated with METTL3 mRNA levels in ESCC tumors (N = 215, SYSUCC cohort; Figure 2C), indicating that METTL3 is the main methyltransferase that catalyzes the m6A modification of the TNFR1 transcript.