Based on inhibitory effects of broussonin A and B on angiogenic responses, we next examined the ability of broussonin A and B to regulate proliferation and invasion in NSCLC p53 wild‐type A549 and p53‐deficient H1299 cells as well as ovarian cancer p53‐deficient SKOV‐3 cells (Figure 7). This evidence concerns the gene TP53 and non-small cell lung carcinoma.