RECQL5 (MIM: 603781), where variant rs820198 is located, regulates DNA repair intermediate structures, and studies have observed elevated RECQL5 expression in other cancers such as breast (MIM: 114480) and bladder (MIM: 109800).70, 71, 72 Variant rs820198 is annotated to an active CTCF (CCCTC-binding factor, MIM: 604167) binding site, and CTCF expression is linked to poor outcomes in PC.73 Here, CTCF is linked to cancer.