It also indicated that global cognitive function in this cohort was positively correlated with education (PVE = 0.0020, P = 5.57e−3), inversely correlated with APOE4 allele count (PVE = 0.035, P = 5.00e−6), a diagnosis of Parkinson’s disease (PVE = 0.042, P = 7.49e−7), neocortical Lewy body disease (PVE = 0.016, P = 5.49e−4), hippocampal sclerosis (PVE = 0.014, P = 1.03e−3) and marginally age (PVE = 0.0047, P = 9.89e−2). The gene discussed is APOE; the disease is Parkinson disease.