And the iNOS has been linked to the cochlear pathology through blood flow to the middle ear, outer hair cell, and vestibular functions in sensorineural HL [62,63], as well as brain diseases like parkinson’s disease (PD), alzheimer’s disease (AD), amyotrophic lateral sclerosis (ALS), huntington's disease (HD), autism spectrum disorder (ASD), and stroke [64]. This evidence concerns the gene NOS2 and early-onset autosomal dominant Alzheimer disease.