, 2000; Schwaller et al., 2002) and significant reduction in parvalbumin expression is reported from PNs of SCA1 (spinocerebellar ataxia 1) patients (Vig et al., 1996) and transgenic mice carrying the human SCA1-causing gene (Vig et al., 1998). Here, PVALB is linked to spinocerebellar ataxia type 1.