Furthermore, fly mutants in Lipin, a phosphatidate phosphatase required for normal insulin pathway signalling that plays a central role in FB function and energy metabolism, Seipin, a transmembrane protein with roles in ER calcium homeostasis and lipid storage, or Sik3 (Salt-inducible kinase 3), a kinase involved in lipid catabolism by regulating bmm gene expression show reduced lipid content and lipodystrophy (Li et al., 2019). This evidence concerns the gene SIK3 and lipodystrophy.