Recently, Wu et al. (2018) demonstrated that conditional knockout of METTL3 in BMSCs increased bone loss, leading to impairment of bone formation and development of the pathological characteristics of osteoporosis in mice, indicating that downregulation of METTL3-mediated m6A methyltransferase in BMSCs induced osteoporosis. The gene discussed is METTL3; the disease is osteoporosis.