Our study confirms that both YTHDF1/3 and YTHDC1/2 are highly expressed in metastatic melanoma, and of interest, the high expression of YTHDF1 in patients with metastatic melanoma is accompanied by an indication of a poorer prognosis, which suggests a new direction for deeper studies of molecules containing YTH domain. This evidence concerns the gene YTHDC1 and metastatic melanoma.