The expression of m6A regulators with aberrant CNV amplification was also upregulated in metastases compared to primary melanoma (ALKBH5, FMR1, HNRNPA2B1, IGF2BP1/2/3, KIAA1429, YTHDC1, YTHDF1/3), and conversely, m6A regulators with aberrant CNV deletion were also downregulated (METTL3, RBM15B, YTHDC2), which are obtained by combining Figure 1D. The gene discussed is YTHDF1; the disease is melanoma.