Comparing primary melanoma and metastases, we found that ALKBH5, ELAVL1, FMR1, HNRNPA2B1, HNRNPC, IGF2BP1/2/3, KIAA1429, LRPPRC, RBM15, YTHDC1/2, YTHDF1/3, and ZC3H13 were significantly upregulated in metastases, while RBM15B and METTL3 were significantly upregulated in primary melanoma (Figure 1E). The gene discussed is RBM15B; the disease is melanoma.