BRAF and melanoma: More deeply, we performed significant mutation gene (SMG) analysis of melanoma samples based on m6Sig score, and the waterfall plot of mutation landscape noted that BRAF (54%/48%), SIRPB1(11%/5%), and KNSTRN (7%/2%) had higher somatic mutation rates in the high-score group, although BRAF was not statistically significant (Figure 5G).