As relevant studies on the effect of angiogenesis inhibition on rosacea development have not been published, we used a previously described rosacea-like mouse model via intradermal injection of LL37 and discovered VEGFR2 inhibitor Cabo treatment significantly reduced the severity of erythema, immune cell infiltration and angiogenesis in the dorsal skin of mice induced by LL37. Here, KDR is linked to Erythema.