reported that the expression of certain hub genes (CDKN3, TPX2, BUB1B, CDCA8, UBE2C, NDC80, RRM2, NCAPG, NCAPH, PTTG1, FAM64A, ANLN, KIF4A, CEP55, CENPF, KIF20A, ASPM, and HJURP) was closely associated with overall survival and recurrence-free survival of patients with ccRCC using KEGG pathway analysis and PPI network construction (15). The gene discussed is TPX2; the disease is nonpapillary renal cell carcinoma.