After the LASSO-Cox analysis, we identified five independent predictors (FSCN1, SLC17A9, ANKRD13B, ADCY2, and MAPT) to construct a prognostic model, which can recognize the genome difference among patients with ccRCC and divide these patients into the high-risk and the low-risk groups. Here, FSCN1 is linked to nonpapillary renal cell carcinoma.