PTPN22 and thyroid gland carcinoma: Using the bioinformatics method to analyze Oncomine database, it was found that HT-related genes (TSHR, BACH2, RNASET2, CTLA4, PTPN22, IL2RA) were also expressed in thyroid cancer, of which TSHR was especially highly expressed while immune-related genes such as BACH2, CTLA4, PTPN22, and IL2RA significantly decreased, as shown in Figure 1.