1) Thyroid specific gene: TSHR is a thyroid hormone receptor, which is highly related to autoimmune thyroid diseases; FOXE1 participates in thyroid morphogenesis, binds to the promoter region of thyroglobulin and thyroid peroxidase, and participates in the expression of thyroglobulin and thyroid peroxidase. This evidence concerns the gene TSHR and autoimmune thyroid disease.