Compared with HT, PTC-specific mutant genes MUC16, HLA-DRB5, NDUFB2, MKI67, XRCC1, IL6R, SOAT1, FAM129A, SLC4A3, KDR, CD74, CDKN1A, ROS1, BRAF, TG, CD44, CCND1, TP53 and BIRC5 were detected. The gene discussed is BIRC5; the disease is hematocrit.