The TF–target gene network showed that the target genes of COPS5 in breast cancer were CDKN1B and VEGFA (Figure 5C), which were suggested to block G1 growth induced by COPS5 in MDA-MB-453 cells (30), promote breast cancer progress via the HIF1A signaling pathway, and degrade p53 (31). This evidence concerns the gene HIF1A and breast carcinoma.