The expression of COPS5, HDAC2, HNRNPD, NONO, PTMA, SIM2, ZNF250, and ZNF706 was significantly higher in breast cancer tissue than that in normal tissue, whereas ALX3 and TBPL1 exhibited higher expression in normal tissue than in breast cancer tissue (Figure 6A). The gene discussed is HDAC2; the disease is breast carcinoma.