It can be seen that patients without liver metastasis (Figure 1E) shared major aberrant pathways with patients with liver metastasis (Figure 1F), including human papillomavirus infection, MAPK signaling pathway, PI3K-Akt signaling pathway, and focal adhesion, etc. Difference existed in some pathways or functions with small amount of mutations, including Wnt signaling pathway, endocytosis, phospholipase D signaling pathway, and Hippo signaling pathway, etc. These observations suggested that no substantial but small differences were found between the two groups in aberrant signaling pathway. Here, AKT1 is linked to human papilloma virus infection.