SKA3 and rectal cancer: SKA3 was highly expressed in a variety of tumors, such as liver (Hou et al., 2019), lung (Dan-Dan et al., 2020), cervical (Hu et al., 2018), rectal cancer (Chuang et al., 2016), etc. These results suggested that SKA3 might play an important role in the formation and proliferation of tumors, and could be an oncogene in the occurrence and development of breast cancer.