NFKB1 and Alzheimer disease: According to previous reports, a wealth of information is linking an exacerbation of Aβ-activated microglia via TLR (toll-like receptor) and upregulated NF-kB signalling for release of the cytokines (TNF-α and IL-1β), which in turn contribute to facilitate AD pathogenesis associated with a subsequent neuronal death [5,27].