KCNH2 and torsades de pointes: Additionally, early COVID-19 therapies such as hydroxychloroquine and azithromycin were known to carry an increased risk for arrhythmias.15 These medications can inhibit hERG potassium channels, which are responsible for the rapid delayed rectifier current (IKr).16 The resultant prolongation of the cardiac action potential and increased early afterdepolarization leads to a prolonged QT interval and increased risk for torsade de pointes (TdP).17