Our study also found different pathological types of PD-L1 expression differences, among which 149 were squamous carcinoma, 131 cases of adenocarcinoma, and other non-small-cell lung cancer, 15 cases among them, respectively, squamous carcinoma in the nonexpression group was 34%, 59%, and 6%, in the low-expression group 58%, 39%, and 3%, and in the high-expression group 54%, 39%, and 7% (P < 0.05); adenocarcinoma expression rate in the low-expression group is higher than that in the nonexpression group and the high expression group, with statistical significance (P < 0.05). This evidence concerns the gene CD274 and squamous cell carcinoma.