The primary pathways included lipid and atherosclerosis, AGE-RAGE signaling pathway in diabetic complications, fluid shear stress and atherosclerosis, hepatitis B, prostate cancer, chemical carcinogenesis-receptor activation, pancreatic cancer, bladder cancer, IL-17 signaling pathway, and hepatitis C. Some of these pathways have been reported to be closely related to UC. This evidence concerns the gene IL17A and hepatitis C virus infection.