A comparison of enriched pathways in both tissues indicated that 17 (FDR<0.05) pathways were commonly enriched for DMR genes in both tissues (SupplementaryTable S6F), including cGMP-PKG signaling pathway, MAPK signaling pathway, Oxytocin signaling pathway, Cushing syndrome, Arrhythmogenic right ventricular cardiomyopathy (ARVC) and Gastric acid secretion, etc. Furthermore, we compared the BP GO terms and pathways enriched for DMR genes with BP GO terms and pathways enriched for DE genes (Ibeagha-Awemu et al., 2021) in both tissues. The gene discussed is OXT; the disease is Cushing syndrome.