Several disease and immune elated pathways were enriched for IL DMR genes, including C-type lectin receptor signaling pathway (FDR = 0.018), Inflammatory mediator regulation of TRP channels (FDR = 0.024), Cushing syndrome (FDR = 0.023); Hepatitis B (FDR = 0.037), Prostate cancer (FDR = 0.038), Non-small cell lung cancer (FDR = 0.037), Pancreatic cancer (FDR = 0.044), etc. Interestingly, some genes (n = 21) were enriched in many pathways, from 4 to 23 pathways (Supplementary Table S6E). This evidence concerns the gene CLEC4D and hepatitis B virus infection.