Majority of the pathways enriched for IL DMR genes were highly interconnected (Figure 6) and notable ones like MARK Signalling pathway, C-type lectin receptor signaling pathway, Cushing syndrome, Inflammatory mediator regulation of TRP channels, cAMP signaling pathway have reported associations with JD and other mycobacterial infections (Rybaczyk et al., 2009; Ariel et al., 2020; Ibeagha-Awemu et al., 2021) or are being associated with JD for the first time. Here, MARK1 is linked to Cushing syndrome due to macronodular adrenal hyperplasia.