Hsa_circ_0001445 could regulate VEGFA mRNA through binding to SRSF1 in glioblastoma, while in HCC, it sponged miR-17–3p and miR-181b-5p to induce the expression of TIMP3 in order to inhibit growth and metastasis. The gene discussed is TIMP3; the disease is hepatocellular carcinoma.