Six AD-associated variants reached significance in the parental-longevity GWAS after correcting for multiple comparisons (FDR<5%): variants in the APOE gene (rs429358 and rs7412) and those in/near PRKD3 (rs8764613), CD2AP (rs9381564), APH1B (rs117618,017) and BIN1 (rs6733839). This evidence concerns the gene APH1B and Alzheimer disease.