Apart from APOE-associated SNPs, for which the effects on several neurological diseases, cardiovascular diseases as well as diabetes are well known (Liu et al., 2019), the other SNPs in this group were not associated with age-related diseases, although their associated genes have been linked to cardiovascular diseases (PLCG2, ACE, FERMT2) (Hoffmann et al., 2017; Koyama et al., 2020), cancer (FERMT2), (Conti et al., 2021), and diabetes (ACE). This evidence concerns the gene ACE and nervous system disorder.