However, such unexpected effects are not new: for example, in a targeted study of SNPs in IPMK and IP6K3 genes, authors showed that a SNP in IP6K3 increased both the risk of late-onset AD and longevity, while SNPs in IPMK and UCP4 genes were associated with a lower risk of both late-onset AD and longevity (Dato et al., 2021). This evidence concerns the gene SLC25A27 and Alzheimer disease.