For example, for the intergenic variant rs6733839 close to BIN1 gene, we observed a larger effect on AD compared to cognitively healthy aging (EADBIN1 = 0.17, SE = 0.01 and ELGVBIN1 = –0.14, SE = 0.08, p = 0.09), yet in the expected direction. The gene discussed is BIN1; the disease is Alzheimer disease.