ADAM10 and Alzheimer disease: Finally, variant rs593742 near ADAM10 gene (EADADAM10 = 0.08, SE = 0.01 and ELGVADAM10 = 0.06, SE = 0.09, p = 0.49) associated with higher odds of both AD and longevity (unexpected direction of effect), with a resulting IED largely on the unexpected side with fewer data points on the expected direction (due to large confidence intervals).