PTK2B and obesity due to melanocortin 4 receptor deficiency: In line with this hypothesis, genes PTK2B, KANSL1 and ADAM10 have been previously associated with obesity and BMI (Hoffmann et al., 2018; Kichaev et al., 2019; Christakoudi et al., 2021), while ABCA7 and ADAM10 have been associated with blood pressure (Surendran et al., 2020; Bone et al., 2021).