APOE and Alzheimer disease: We compared the direction of effect on longevity with that on AD as found in literature: of the 38 variants, 28 showed an association in the expected direction, i.e., alleles that increased AD risk were associated with lower odds of longevity, and this was significantly more than expected by chance (p = 0.005 including APOE variants, p = 0.01 excluding APOE variants, see 2.2 Methods).