DUSP10 and persistent truncus arteriosus: To investigate whether MKP-5 is involved in regulating Ly6Clow macrophages in response to pressure overload-induced cardiac fibrosis, we examined the expression of MKP-5 in FACS-sorted Ly6Clow cardiac macrophages from Mkp-5+/+ and Mkp-5-/- mice after TAC.