Although the implications of TRANK1 gene in BD remained largely unclear, a newly published large-scale analyses of mRNA co-expression network revealed that genes closely interact with TRANK1, such as glycogen synthase kinase-3 (GSK-3α/β), were engaged in the modulation of synaptic plasticity, neural growth, as well as circadian rhythm (6). Here, TRANK1 is linked to Behcet disease.