We first analyzed the inflammatory state of ear lesions in psoriasis-like mice, and the meta-analysis showed that IL-23 mRNA levels in the ear lesions of psoriatic mice were significantly decreased (MD: −4.35; 95% CI: −7.64 to −1.06; p=0.009, Supplementary Figure 3) in the S1PR agonist group, while the ear inflammatory cell influx (Supplementary Figure 4) and IL-17 mRNA production did not change markedly (p>0.05, Supplementary Figure 5). This evidence concerns the gene IL17A and psoriasis.