CD4 and Chronic colitis: Note that in this chronic colitis model, transfer of Treg-depleted CD4+CD45RBlo T cells into RAG-1-/- mice was characterized by a Th1<Th17 cytokine signature in the colon tissues, whereas transfer of CD4+CD45RBhi naïve T cells demonstrated a Th1>Th17 cytokine signature (84).