More relevant to the context of this review, although many reports suggest a detrimental effect of IL-22BP at blocking the protective effects of IL-22 in acute colitis (75, 86, 87), the role of IL-22BP in chronic IBD, in addition to its beneficial effect on blocking IL-22-mediated tumorigenesis (87) and in acute polymicrobial sepsis (88), warrants further investigation. This evidence concerns the gene IL22RA2 and Sepsis.