Mice that lack ILCs in addition to T cells and B cells (Rag1–/–Il-2rg–/–) show high CDI-associated mortality rates and during CDI Rag1–/– mice showed upregulated expression of ILC-1 and ILC-3 associated proteins (Abt et al., 2015). Here, IL2RG is linked to clostridium difficile infection.