In the same line, one could also speculate about a potential role of toll-like receptor signaling since CDT is recognized by the TLR2/6 heterodimer to induce an NF-κB response and, TLR signaling in human antigen-presenting cells regulates MR1-dependent activation of MAIT cells (Ussher et al., 2016; Simpson et al., 2020). Here, TLR2 is linked to isolated focal cortical dysplasia type II.