This syndrome can cause HA, PCO, ovulation disorders (ODs), elevated levels of luteinizing hormone (LH), and an imbalance in the ratio of luteinizing hormone to follicle stimulating hormone (LH/FSH); some patients also have metabolic changes such as IR/hyperinsulinemia, obesity, and dyslipidemia. The gene discussed is BRD2; the disease is hyperinsulinism.