PLOD1 and obesity due to melanocortin 4 receptor deficiency: This syndrome can cause HA, PCO, ovulation disorders (ODs), elevated levels of luteinizing hormone (LH), and an imbalance in the ratio of luteinizing hormone to follicle stimulating hormone (LH/FSH); some patients also have metabolic changes such as IR/hyperinsulinemia, obesity, and dyslipidemia.