Currently, the pathogenesis of PCOS is not yet completely understood and is still under continuous research, but a number of studies have suggested that HPO axis dysfunction, elevated androgen, IR/hyperinsulinemia, elevated LH/FSH ratio, obesity, oxidative stress, and impaired negative feedback regulation of steroid hormones can all promote the occurrence and development of PCOS (11, 21, 23–25). Here, PLOD1 is linked to Obesity.