Considering the underlying mechanisms of protective role of Tβ4 in heart injuries, previous studies reported that treatment with Tβ4 in the myocardial infarction setting improves cardiac function by activating Akt phosphorylation, promoting the ILK-Pinch-Parvin complex, and suppressing NF-κB. The gene discussed is NFKB1; the disease is myocardial infarction.