NR1H4 and obesity due to melanocortin 4 receptor deficiency: BAs, as pleiotropic signaling molecules, regulate its’ own homeostasis, affecting the metabolism of glucose, lipids and energy, and thus participate in the formation of obesity by binding to nuclear receptors such as the farnesoid X-activated receptor (FXR) and takeda G-protein-coupled receptor 5 (TGR5) (Cipriani et al., 2010; Chiang, 2013; Yuan and Bambha, 2015).