However, conventional markers of myocardial injury, such as troponin (Yeh Michoset al., 2014) or brain natriuretic peptide (Takase and Dohi, 2014), may generally be chronically elevated due to the decrease of clear renal function, which cannot accurately assess the risk of cardiovascular events in patients with CKD. The gene discussed is NPPB; the disease is chronic kidney disease.