FGF23 and Myocardial fibrosis: The stimulation of this pathway by FGF23 could uniquely act on the FGFR 4 receptor in cardiomyocytes, then prevent part of the function of FGFR, inhibit myocardial hypertrophy-related genes, and slow down the process of myocardial hypertrophy and myocardial fibrosis (Grabner et al., 2015).