A study showed that patients with chronic kidney disease with lower eGFR levels had higher levels of plasma IL-1 β, IL-1RA, IL-6, TNF-α, hypersensitive CRP, and fibrinogen and that the inflammation score was inverted with GFR estimates and urinary albumin/creatinine ratio (UACR) (Gupta et al., 2012). The gene discussed is TNF; the disease is chronic kidney disease.