However, the oxidation in the CKD process, the low reactivity of parathyroid hormone, and the accumulation of inhibitory C-terminal fragments at the target tissue level affect the accuracy of PTH in evaluating CKD-MBD to a certain extent (Katherine et al., 2010; Evenepoel et al., 2016). The gene discussed is PTH; the disease is Marchiafava-Bignami disease.