On the contrary, some opposite evidence indicated that low mir-192 expression could be detected in tubular cells cultured with high TGF-β1 and glucose, which is similar to the renal biopsy samples obtained from patients with DN under decreased eGFR and tubulointerstitial fibrosis (Kato et al., 2007; Wang et al., 2010). Here, TGFB1 is linked to liver dysplastic nodule.