BDNF and Huntington disease: It has been proposed that the drug may reduce nerve damage and improve motor function by blocking the activity of the enzyme transglutaminase, shown to be increased in HD patients and involved in nerve injury, by increasing the secretion of the brain-derived neurotrophic factor (BDNF) that improves neuron survival and function, and by other still unidentified mechanisms (Dedeoglu et al., 2002; Karpuj et al., 2002; Van Raamsdonk et al., 2005; Bailey and Johnson, 2006; Borrell-Pages et al., 2006; Arbez et al., 2019).