In line with that, several compounds with NRF2-inducing activity, such as sulforaphane, the anti-epileptic drug dyclonine, DMF, N-acetyl cysteine, and omaveloxolone among others, showed beneficial effects and frataxin-inducing activity in different models of FRDA (Petrillo et al., 2017; Clay et al., 2019; Petrillo et al., 2019). Here, FXN is linked to Friedreich ataxia.