SLC5A2 and kidney disorder: To address this point, this study examined the nephroprotective effect of EMPA in uninephrectomized wildtype mice and four different kidney disease mouse models with varying degrees of glomerular damage/albuminuria, referring to an early clinical study that linked the occurrence of renal benefits by SGLT2 inhibition with the patient’s stage of renal impairment at therapy initiation (Rajasekeran et al., 2018).