As seen in other rodent studies (Kapoor et al., 2015; Rajasekeran et al., 2018; Castoldi et al., 2020; Yamato et al., 2020; Castoldi et al., 2021), SGLT2 inhibition caused significant or at least a strong trend towards renal hypertrophy in our animal models under hyperfiltrating conditions, but also in healthy kidneys. Here, SLC5A2 is linked to cardiac hypertrophy.