Moreover, the immediate reduction in diabetic glomerular hyperfiltration appears to be a common event in patients on SGLT2 inhibitors and is likely critical for long-term maintenance of GFR and prevention of progressive kidney damage (Kohan et al., 2016; Wanner et al., 2016; Perkovic et al., 2018; Perkovic et al., 2019). The gene discussed is SLC5A2; the disease is Nephropathy.