CASP3 and colonic neoplasm: Sambrani et al. demonstrated, in HT-29 colon cancer cells, that treatment with Saccharomyces cerevisiae (S. cerevisiae) caused a significant upregulation in the expression of PTEN and caspase-3, while the expression levels of Bcl-xL and RelA were markedly decreased after probiotic intervention (Sambrani et al., 2019).