A study regarding therapeutic target for APOE4 by Wadhwani et al. (2019) showed that when the E4 allele was corrected to E3/E3 genotype in iPSCs from two patients with AD via CRISPR/Cas9 method, E3 neurons were less susceptible to ionomycin-induced cytotoxicity, and exhibited a decrease in tau phosphorylation. Here, APOE is linked to Alzheimer disease.