Here, we combine data of patients with Alzheimer's disease and normal people to further explore the underlying pathogenesis of Alzheimer's disease and finally conclude that miR-590-3 and SP1 are key regulatory genes to Alzheimer's disease, which can encourage neuronal apoptosis in patients with Alzheimer's disease through the AMPK signaling pathway. This evidence concerns the gene SP1 and early-onset autosomal dominant Alzheimer disease.