Reviewing the global (Figure 3(c)), we also found that the key genes miR-590-3 and SP1 affecting neurons in Alzheimer's disease may jointly contribute to the apoptosis of neurons in Alzheimer's disease by targeting CREB1 to mediate the involvement of module 2 in the AMPK signaling pathway and enhance the neuronal apoptosis in patients with Alzheimer's disease. This evidence concerns the gene CREB1 and Alzheimer disease.