APP and neuroblastoma: Mechanistically, Kaem and Rhap reduced Aβ production as supported by decreased levels of FL-APP, CTF-β and CTF-α in the hippocampal tissue of the 3xTg AD mice (Fig. 6j–l and Extended Data Fig. 4a), mirroring the results seen in the N2a mouse neuroblastoma cells (Extended Data Fig. 1c–f).