Mechanistically, Kaem and Rhap reduced Aβ production as supported by decreased levels of FL-APP, CTF-β and CTF-α in the hippocampal tissue of the 3xTg AD mice (Fig. 6j–l and Extended Data Fig. 4a), mirroring the results seen in the N2a mouse neuroblastoma cells (Extended Data Fig. 1c–f). The gene discussed is APP; the disease is Alzheimer disease.