While basal autophagy was lower in the hippocampal tissue of the 3xTg AD mice (lower LC3B-II/LC3B-I and higher p62) compared with WT mice, administration of Kaem and Rhap increased autophagy in the 3xTg AD mice (Extended Data Fig. 4f,k,l). Here, SQSTM1 is linked to Alzheimer disease.