MAPT and tauopathy: In addition to alleviating Aβ pathology, we asked whether Kaem and Rhap protect against tauopathies by using the well-characterized CK12 (hTau4R1N(P301L)44, pan-neuronal expression) and BR5270 (with pro-aggregant hTau(F3Δ280) tau fragment45, pan-neuronal expression) strains.