Impairment of the cholinergic system plays an important role in the pathophysiology of AD, and cholinergic therapies serve as a standard pharmacological approach in AD42.To investigate the effect of Kaem or Rhap on synaptic transmission of acetylcholine, pan-neuronal hAβ1–42 worms were exposed to an acetylcholinesterase inhibitor, aldicarb, and the time-course of paralyzing effects was scored43. This evidence concerns the gene ACHE and Alzheimer disease.