Moreover, as shown by KDM4B’s epigenetic modulation of ERα and KDM6B’s physical interaction with ERα in breast cancer cells, there is a possibility that a positive feedback loop exists whereby KDM6B epigenetically promotes ERα transcription.58,59,61 Notably, further mechanisms responsible for regulating KDM6B expression during osteogenic differentiation are being elucidated. Here, ESR1 is linked to breast cancer.