ESR1 and breast cancer: Upon E2 induction, KDM6B and ERα work in concert to demethylate the H3K27me3 mark from the poised enhancer region of the ERα-regulated antiapoptotic gene BCL2, leading to the prevention of breast cancer cell death.61 These findings highlight the dynamic and important role of histone demethylases in the epigenetic control of estrogen and ERα pathways.