IDH1 and central nervous system cancer: Compared to lower grade gliomas with IDH1 mutation and non-1p/19q codeletion (IDH1-Mut-noncodel, LGG), TMEM158 mRNA expression was higher in lower grade gliomas with IDH1 mutation and 1p/19q codeletion (IDH1-Mut-codel, LGG) (Fig. 1E–G).