Approximately 40% of acute ischemic strokes are caused by proximal intracranial large vessel occlusions (LVO) that are also associated with poor clinical outcomes.1,2 Current management strategies for patients with ischemic stroke due to LVO include early reperfusion with intravenous tissue-type plasminogen activator (tPA) and/or intra-arterial thrombectomy.3 However, most stroke patients with LVO remain untreated because they diagnosed beyond the optimal time window for acute reperfusion therapies, or are unable to reach major stroke centers that are capable of thrombectomy.1 Here, PLAT is linked to stroke disorder.