Despite their significance in cancer development, a direct relationship between upregulated STn/ST6GALNAC1, PSA/ST8SIA2, and TP53, “the guardian of the genome,” has been rarely considered, except for TP53 mutants being implicated in the N-glycosylation of proteins via the UDPase, ENTPD5 [45], and the correlated expressions of STn and Tp53 protein in a mouse model of bladder cancer [44]. Here, ENTPD4 is linked to cancer.