Further, high AD also displayed significantly higher area fraction of p-tau 217 compared to PART (p = 0.0008), non-AD tauopathies (p = 0.004) and intermediate AD (p = 0.018) when the mean values of EC, CA1, and ITG (M1; n = 27) were analyzed (Fig. 4E). This evidence concerns the gene MAPT and tauopathy.